It will support almost any existing audio interface. REAPER converts your computer into the full power of any top-of-the-line recording studio. It is suitable for recording anything from a soloist to a band to an orchestra.
If you add a hardware audio interface of your choice (AD/DA: analog-to-digital/ digital-to-analog) and a microphone, you have a complete recording studio. Using your current computer and no other software, you can import any audio and MIDI, synthesize, sample, compose, arrange, edit, mix, and master songs or any other audio projects. It is a complete multitrack audio and MIDI recording, editing, processing, mixing, and mastering environment.